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After runs 2 and 4, when you change kappa or phi, set the focus back to its original value, and repeat the Sample centering steps. Although you probably will not need to change the camera focus. If you leave the camera focus at the same value, the adjustment of Sample X will be much smaller.
After data collection, it is a good idea to return Omega to zero and recenter the DAC before changing Kappa and Phi back to Zero. This way, when you put the next DAC on the goniometer, it will be in approximately the right place.